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Central Line-Associated Bloodstream Infections (CLABSIs) pose a significant financial burden on hospitals, leading to increased hospital stays, additional medical treatments, and higher use of healthcare resources. Each CLABSI case can cost hospitals between $22,000 to $100,000, depending on the severity and interventions required. Additionally, hospitals may face penalties from insurance companies and reduced reimbursements from Medicare and Medicaid due to high infection rates. These financial strains emphasize the importance of investing in preventive measures and staff training to reduce CLABSI incidence. The Finanical Impact of CLABSI A detailed study conducted at a tertiary-care academic medical center found that CLABSI significantly increased hospital costs and mortality risk. The study revealed that adjusted variable costs for CLABSI patients were approximately $32,000 higher than for those without CLABSI (in 2010 US dollars). Moreover, CLABSI was associated with a 2.27-fold increased risk of in-hospital mortality after adjusting for illness severity and other healthcare-associated infections. These findings highlight the substantial financial burden and elevated mortality risk linked to CLABSI in both ICU and non-ICU settings. Antibiotic Resistance The issue is further complicated by antibiotic resistance. Antibiotic-resistant pathogens in CLABSI cases complicate treatment, leading to longer hospital stays, increased healthcare costs, and higher mortality rates. These infections require more complex...